KMID : 1100720190390060537
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Annals of Laboratory Medicine 2019 Volume.39 No. 6 p.537 ~ p.544
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Serotype Distribution and Antimicrobial Resistance of Invasive and Noninvasive Streptococcus pneumoniae Isolates in Korea between 2014 and 2016
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Park Dong-Chul
Kim Si-Hyun Yong Dong-Eun Suh In-Bum Kim Young-Ree Yi Jong-Youn Song Won-Keun Song Sae-Am Moon Hee-Won Lee Hae-Kyung Park Kyoung-Un Kim Sun-Joo Jeong Seok-Hoon Lee Jae-Hyeon Jeong Joseph Kim Yu-Kyung Lee Mi-Ae Cho Ji-Hyun Kim Jong-Wan Shin Kyeong-Seob Hwang Sang-Hyun
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Abstract
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Background: Several factors contribute to differences in Streptococcus pneumoniae serotype distribution. We investigated the serotype distribution and antimicrobial resistance of S. pneumoniae isolated between 2014 and 2016 in Korea.
Methods: We collected a total of 1,855 S. pneumoniae isolates from 44 hospitals between May 2014 and May 2016, and analyzed the serotypes by sequential multiplex PCR. We investigated the distribution of each serotype by patient age, source of the clinical specimen, and antimicrobial resistance pattern.
Results: The most common serotypes were 11A (10.1%), followed by 19A (8.8%), 3 (8.5%), 34 (8.1%), 23A (7.3%), and 35B (6.2%). The major invasive serotypes were 3 (12.6%), 19A (7.8%), 34 (7.8%), 10A (6.8%), and 11A (6.8%). Serotypes 10A, 15B, 19A, and 12F were more common in patients ¡Â5 years old, while serotype 3 was more common in patients ¡Ã65 years old compared with the other age groups. The coverage rates of pneumococcal conjugate vaccine (PCV)7, PCV10, PCV13, and pneumococcal polysaccharide vaccine 23 were 11.8%, 12.12%, 33.3%, and 53.6%, respectively. Of the 1,855 isolates, 857 (46.2%) were multi-drug resistant (MDR), with serotypes 11A and 19A predominant among the MDR strains. The resistance rates against penicillin, cefotaxime, and levofloxacin were 22.8%, 12.5%, and 9.4%, respectively.
Conclusions: There were significant changes in the major S. pneumoniae serotypes in the community. Non-PCV13 serotypes increased in patients ¡Â5 years old following the introduction of national immunization programs with the 10- and 13-polyvalent vaccines.
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KEYWORD
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Streptococcus pneumoniae, Serotype, Antimicrobial resistance, Pneumococcal vaccine
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