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KMID : 1100820120020010020
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Laboratory Medicine Online
2012 Volume.2 No. 1 p.20 ~ p.27
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Significance of Serum Eosinophil Cationic Protein and High-Sensitivity C-reactive Protein Levels in Patients with Allergic and Non-Allergic Inflammatory Diseases
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Jang Woo-Ri
Choi Jong-Won
Nahm Chung-Hyun
Moon Yeon-Sook
Kim Jin-Ju
Kim Jeong-Hee
Lim Dae-Hyun
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Abstract
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Background: This study was conducted to evaluate the significance of serum eosinophil cationic protein (ECP) and high-sensitivity C-reactive protein (hs-CRP) levels in children with allergic diseases and non-allergic inflammatory diseases, and to assess the relationships between serum ECP levels and inflammatory parameters.
Methods: In this study, we included 146 children with allergic diseases, 76 children with non-allergic inflammatory diseases, and 25 control subjects. Serum concentrations of ECP, hs-CRP, total IgE, and allergen-specific IgE were measured.
Results: Serum ECP levels (77.5±88.2 μg/L) of patients with allergic diseases were significantly higher than those of the patients with non-allergic inflammatory diseases (42.2±58.8 μg/L) and control subjects (12.7±4.2 μg/L) (P<0.001, respectively). The serum ECP levels in patients with non-allergic inflammatory diseases were also significantly higher than those in the controls (42.2±58.8 vs. 12.7±4.2 μg/L; P<0.001). The hs-CRP levels were significantly higher in patients with allergic diseases than in the controls (0.4±0.9 vs. 0.1±0.2 mg/dL; P<0.05). No significant relationship was observed between serum ECP and hs-CRP levels in the allergic patients (r=0.09, P>0.05).
Conclusions: Measurement of serum ECP and hs-CRP concentrations can be helpful in the clinical evaluation and monitoring of patients with allergic diseases. No significant correlation was observed between serum ECP and hs-CRP levels in allergic patients, thereby suggesting that elevated levels of ECP do not necessarily reflect the degree of systemic inflammation in allergic diseases.
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KEYWORD
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Eosinophil cationic protein, High sensitivity C-reactive protein, Eosinophil, Immunoglobulin E, Allergic disease
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