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KMID : 1100820120020030166
Laboratory Medicine Online
2012 Volume.2 No. 3 p.166 ~ p.169
Autoimmune Hemolytic Anemia after Aplastic Crisis due to Parvovirus B19 Infection in a Patient with Hereditary Spherocytosis
Song Sae-Am

Lee Min-Young
Kim Si-Hyun
Lee Ja-Young
Oh Seung-Hwan
Shin Jeong-Hwan
Kim Hye-Ran
Jun Kyung-Ran
Lee Jeong-Nyeo
Abstract
Hereditary spherocytosis (HS) is a genetic disorder characterized by the production and destruction of spherocytes due to a deficiency of red cell membrane cytoskeletal proteins, resulting in the clinical presentation of chronic hemolytic anemia. This disease can be accompanied by an aplastic crisis due to parvovirus B19 infection. Parvovirus B19 infection causes diseases such as erythema infectiosum and arthritis, and can also trigger various autoimmune diseases, including autoimmune hemolytic anemia (AIHA). Here, we report a rare case of AIHA developing 3 months after an aplastic crisis due to parvovirus B19 infection in an 11-year-old boy with HS and provide the relevant literature review.
KEYWORD
Hereditary spherocytosis, Parvovirus B19, Autoimmune hemolytic anemia
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