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KMID : 1100820120020030174
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Laboratory Medicine Online
2012 Volume.2 No. 3 p.174 ~ p.178
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Cholestasis Causes Discrepancy in HDL-Cholesterol Levels Measured Using Various Methods
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Kim Sol-Iip
Chun Sa-Il
Lee Woo-Chang
Kim Ghi-Su
Min Won-Ki
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Abstract
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Herein, we report a case in which cholestasis caused discrepancy in high-density lipoprotein (HDL)-cholesterol levels measured using various methods. The discrepancy in HDL-cholesterol level originated from the abnormal increase in the level of an unusual lipoprotein, apo E-rich HDL, in the patient's serum. An abnormal slow alpha-migrating lipoprotein was observed on agarose gel electrophoresis, and an abnormal large-sized HDL was observed in a lipoprotein subfraction study. The level of apolipoprotein E was elevated.
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KEYWORD
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HDL-Cholesterol, Cholestasis, Discrepancy
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