|
KMID : 1100820130030040259
|
|
Laboratory Medicine Online
2013 Volume.3 No. 4 p.259 ~ p.263
|
|
|
A Case of Platelet Satellitism with Platelet Phagocytosis by Neutrophils and Platelet-neutrophil Agglutination
|
|
Yoon Kui-Hyun
|
|
|
Abstract
|
|
|
|
Platelet satellitism is a rare phenomenon in which platelets adhere to the surface of neutrophils; in addition, platelet phagocytosis by neutrophils and monocytes is rare event. Although its clinical significance and pathophysiology are still unclear, platelet-neutrophil agglutination seems to be the end point of a process that is initiated by platelet satellitism and causes pseudothrombocytopenia and pseudoneutropenia. Differentiating pseudothrombocytopenia is essential to avoid unnecessary diagnostic testing and treatments. This report describes an unusual case of a 64 yr old man who presented with left flank pain and pseudothrombocytopenia, which was caused by platelet satellitism with platelet phagocytosis by neutrophils and platelet-neutrophil agglutination. Platelet satellitism occurred in the presence of ethylenediaminetetraacetic acid (EDTA) at room temperature or 4℃, but not at 37℃; however, platelet-neutrophil agglutination and pseudoleukopenia were observed in EDTA-treated blood only after a 2-hr incubation period at room temperature. Additionally, platelet satellitism could be induced in packed blood cells from a normal individual during a mixing assay with this patient's plasma. To the best of my knowledge, this is the first reported case of platelet satellitism with platelet phagocytosis by neutrophils and platelet-neutrophil agglutination in Korea.
|
|
|
KEYWORD
|
|
|
Platelet satellitism, Platelet phagocytosis, Platelet-neutrophil agglutination
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|