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KMID : 1100820140040010008
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Laboratory Medicine Online
2014 Volume.4 No. 1 p.8 ~ p.14
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Mobilization of Peripheral Blood Stem Cells for Autologous Transplantation in Patients with Hematologic Malignancies
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Kim MIn-Ji
Kim Sang-Gyung
Lee A-Jin
Jang Hae-Bong
Bae Sung-Hwa
Ryoo Hun-Mo
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Abstract
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Background: Autologous peripheral blood-stem cell transplantation (autoPBSCT) is the treatment of choice for hematologic malignancy, because the technique requires neither general anesthesia nor surgical intervention, amongst many other advantages. Despite these benefits, the risk of hematologic malignancy, as well as the effect of patient age and sex on the prediction of successful collection of autoPBSCT are still unclear. The purpose of this study was to examine whether the hematologic diagnosis of the disease, and age or sex affect the mobilization of CD34+ cells and mononuclear cells.
Methods: We retrospectively investigated 30 (6 multiple myeloma, 11 diffuse large B-cell lymphoma, 8 acute myeloid leukemia, 2 acute lymphoid leukemia, and 3 T-cell lymphoma) patients who underwent autoPBSCT between 2008 and 2011 at Daegu Catholic University Hospital.
Results: Patients with multiple myeloma had the highest average of both mononuclear cell (MNC) (2.07±0.67×108 cells/kg) and CD34+ cell (1.28±0.58×106 cells/kg) counts. Patients with T-cell lymphoma had both the lowest MNC (1.23±0.49×108 cells/kg) and CD34+ cell (0.20±0.6×106 cells/kg) counts. Male patients showed greater collected CD34+ cell counts (0.96±1.38×106 cells/kg) and MNC counts (1.71±0.76×108 cells/kg) than the female patients. Patients under the age of 44 had higher collected CD34+ cell counts (0.96±1.37×106 cells/kg) but lower counts of MNC (1.49±0.74×108 cells/kg).
Conclusions: The collected MNC and CD34+ cell counts varied between the types of malignancies, and with respect to sex and age. However, only collected MNC counts were significantly different (P<0.05) among the different types of malignancies.
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KEYWORD
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Hematologic malignancy, Autologous peripheral blood-stem cell transplantation (autoPBSCT), Mononuclear cells, CD34+ cells, Mobilization
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