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KMID : 1100820140040020116
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Laboratory Medicine Online
2014 Volume.4 No. 2 p.116 ~ p.121
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Interferon-γ Release Assay Using Pericardial Fluid and Peripheral Blood for the Diagnosis of Tuberculous Pericarditis: A Case Report
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Park Kyung-Sun
Park Hyung-Doo
Ki Chang-Seok
Lee Nam-Yong
Chang Sung-A
Kang Eun-Sook
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Abstract
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Here, we report a case in which the rapid diagnosis of tuberculous pericarditis was made using Mycobacterium tuberculosis (MTB)-specific interferon-γ release assay on peripheral blood and pericardial effusion. Acid-fast bacilli staining, mycobacterial culture, and nucleic acid amplification targeting MTB using pericardial fluid were negative. However, elevated adenosine deaminase (ADA) activity in pericardial fluid and interferon-γ release assay positivity in both pericardial fluid and peripheral blood indicated the presence of tuberculous pericarditis. After anti-tuberculous and steroid treatment, the patient's clinical symptoms improved, and pericardial effusion has not reoccurred.
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KEYWORD
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Mycobacterium tuberculosis, Interferon-γ release assay, Tuberculous pericarditis
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