|
KMID : 1100820150050030137
|
|
Laboratory Medicine Online
2015 Volume.5 No. 3 p.137 ~ p.142
|
|
|
Platelet Activation Markers (β-thromboglobulin and platelet factor 4) and Clopidogrel Drug Response in Patients with Myocardiac Infarction
|
|
Park Young-Choon
Kim Ji-Myung
Jeong Jin-Ok
Kwon Kye-Chul
Koo Sun-Hoe
|
|
|
Abstract
|
|
|
Background: Dual antiplatelet therapy (aspirin and clopidogrel) is used to prevent adverse cardiac events in patients undergoing percutaneous coronary intervention (PCI). Some patients do not respond adequately to clopidogrel. Beta-thromboglobulin (β-TG) and platelet factor 4 (PF-4) can act as markers to detect platelet activation. We investigated the relationship between clopidogrel response and the dynamics of β-TG and PF4 concentrations.
Methods: This study included 36 myocardial infarction (MI) patients, who underwent PCI and was indicated for dual antiplatelet therapy. Platelet reactivity, using the VerifyNow P2Y12 assay, was measured on the 3rd day of PCI. At the time of admission, and on the 3rd and 10th day of PCI, the plasma β-TG and PF4 concentrations were quantified.
Results: Ten patients (27.8%) were clopidogrel non-responders displaying >208 P2Y12 reaction units. At the time of admission, levels of β-TG in patients were elevated than that in the healthy controls (P<0.001). A similar trend was observed on the 3rd and 10th day of PCI (P<0.001). The β-TG levels on the 10th day were reduced than those at the time of admission and on the 3rd day of PCI. PF4 levels were not different between patients and controls, and were not significantly reduced after PCI. Higher β-TG levels were observed in clopidogrel non-responders on the 10th day, but not significant.
Conclusions: Clopidogrel therapy in MI reduce β-TG concentration, but the β-TG and PF4 levels before and after therapy are not associated with the response to clopidogrel. Platelet-derived markers may not be suitable for distinguishing clopidogrel non-responders.
|
|
|
KEYWORD
|
|
|
Beta-thromboglobulin, Clopidogrel, Myocardial infarction, Platelet factor 4
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|