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KMID : 1100820160060010012
Laboratory Medicine Online
2016 Volume.6 No. 1 p.12 ~ p.18
Human Epididymis Protein 4 as a Diagnostic Marker of Ovarian Cancer and Its Reference Interval in Korean Population
Woo Hee-Yeon

Abstract
Human epididymis protein 4 (HE4), which complements cancer antigen 125 (CA125), has emerged as a new diagnostic biomarker that can discriminate between benign and malignant ovarian tumors. The risk of ovarian malignancy algorithm (ROMA) incorporates CA125, HE4, and menopausal status to classify patients with pelvic masses into those at high or low risk of developing ovarian cancer. The reference interval of HE4 among Korean population was different from those recommended by the manufacturer or evaluated in the Chinese.
KEYWORD
Human epididymis protein 4, Ovarian cancer, Risk of ovarian malignancy algorithm, Reference interval
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KoreaMed