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KMID : 1100820160060020098
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Laboratory Medicine Online
2016 Volume.6 No. 2 p.98 ~ p.101
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A Case of Coexistence of Bone Marrow-involved Refractory Marginal Zone B-Cell Lymphoma and Therapy-related Myelodysplastic Syndrome
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Song Il-Geun
Park Chan-Jeoung
Cho Young-Uk
Seo Eul-Ju
Lee Je-Hwan
Suh Chul-Won
Jang Seong-Soo
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Abstract
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Recent advances in chemotherapy have led to increased survival rates for patients with hematologic malignancies. However, standard chemotherapies, including alkylating agents for non-Hodgkin lymphoma, could induce therapy-related myeloid neoplasms (t-MNs), a group of disorders categorized by the World Health Organization in 2008. Here, we report a case of coexistence of bone marrow (BM)-involved refractory marginal zone B-cell lymphoma (MZL) and therapy-related myelodysplastic syndrome (t-MDS). Simultaneous presence of refractory lymphoma and t-MN in the BM is rare, and this is the first report in Korea. The patient received allogeneic hematopoietic stem cell transplantation (HSCT) to cure both the MZL and t-MDS. Since the HSCT, he has been stable for 21 months without any evidence of recurrence.
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KEYWORD
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Bone marrow, Therapy-related myelodysplastic syndrome, Marginal zone B-cell lymphoma, Allogeneic hematopoietic stem cell transplantation
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