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KMID : 1100820170070030089
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Laboratory Medicine Online
2017 Volume.7 No. 3 p.89 ~ p.93
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Transfusion Strategy of RhD-negative/variant Patients in the Korean Population
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Yang Hyung-Seok
Chun Se-Jong
Lee Sun-Ah
Kwon Jeong-Ran
Choi Young-Sill
Kim Jun-Nyun
Cho Duck
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Abstract
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The prevalence of RhD-negative individuals in the Korean population is approximately 0.15-0.30% and the supply of RhD-negative blood often faces potential shortage. Furthermore, 15-17% of serologically RhD-negative Korean individuals were revealed to be DEL variants and should be treated as RhD-positive when being considered as blood donors. This change is expected to result in a further shortage of RhD-negative blood supply, whereas surplus DEL variant blood stock is created. Therefore, it is now required to amend blood donation and supply policies, and transfusion strategies. In this review, a new transfusion strategy for patients with RhD-negative or variant blood in Korea is discussed, with particular interest in women of child-bearing age, patients with anti-D, and Asia type DEL (c.1227G>A) variants.
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KEYWORD
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RHD, DEL, Transfusion, Genotyping
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