|
KMID : 1100820170070040196
|
|
Laboratory Medicine Online
2017 Volume.7 No. 4 p.196 ~ p.200
|
|
|
A Case of Acute Promyelocytic Leukemia with Co-existence of BCR-ABL1 and PML-RARA Rearrangements Detected by PCR
|
|
An Gyu-Dae
Lim Hyeon-Ho
Woo Kwang-Sook
Kim Kyeong-Hee
Kim Jung-Man
Kim Sung-Hyun
Han Jin-Yeong
|
|
|
Abstract
|
|
|
|
Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia (AML) characterized by PML-RARA fusion and specific morphology. The BCR-ABL1 rearrangement is mainly observed in patients with chronic myeloid leukiemia (CML). However, it is also found in patients with acute lymphoblastic leukemia (ALL) and in a few patients with AML. However, it is very rarely observed in patients with APL. Here, we report a case of APL with t(15;17) and co-existence of PML-RARA and BCR-ABL1. Further study with more cases is warranted to find the right treatment and prognostic significance.
|
|
|
KEYWORD
|
|
|
Acute promyelocytic leukemia, PML-RARA, BCR-ABL1
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|