KMID : 1100820190090020088
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Laboratory Medicine Online 2019 Volume.9 No. 2 p.88 ~ p.93
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A Case of Fungemia with Co-isolation of Candida parapsilosis and Trichosporon asahii Confirmed by MALDI-TOF MS and D2 rRNA Sequencing
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Seo Jong-Do
Kim Nam-Hee Hong Yun-Ji Kim Taek-Soo Hwang Sang-Mee Park Jeong-Su Seong Moon-Woo Park Kyoung-Un Song Jung-Han Park Sung-Sup Kim Eui-Chong
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Abstract
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Fungi are a major cause of human infections with diverse clinical manifestations. The incidence of fungal infections has increased over time, particularly in patients who have risk factors such as neutropenia, immune suppression, an intravascular catheter, parenteral nutrition, a prosthetic device, and prior broad spectrum antibiotic therapy. Here, we present an unusual case of co-infection by 2 distinct fungi, Candida parapsilosis and Trichosporon asahii, isolated from a patient who did not have any known risk factors initially, except active pulmonary tuberculosis. Despite the negative conversion of sputum acid-fast bacilli (AFB) culture test after treatment, clinical symptoms were refractory to therapy. The patient developed symptoms suggesting septic shock, and 2 distinct colonies were isolated from a blood specimen, which were identified as C. parapsilosis and T. asahii by MALDI-TOF and rRNA sequencing. Fever and hypotension were relieved after anti-fungal agent injection, and pulmonary lesions identified by imaging also improved.
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KEYWORD
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Fungemia, Candida parapsilosis, Trichosporon asahii, MALDI-TOF MS, D2 rRNA sequencing
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