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KMID : 1100820210110030162
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Laboratory Medicine Online
2021 Volume.11 No. 3 p.162 ~ p.170
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Establishing Reference Intervals of Whole Blood Viscosity in a Korean Population Using a Cone-Plate Viscometer
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Park Mi-Kyoung
Kim Han-Ah
Moon Hee-Won
Hur Mi-Na
Yun Yeo-Min
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Abstract
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Background: Whole blood viscosity (WBV) is emerging as a biomarker to predict cardio-cerebrovascular and peripheral vascular diseases. This study aimed to establish reference intervals (RIs) of WBV using a cone-plate viscometer, in a Korean population.
Methods: From September to October 2017, the WBV levels of 286 healthy individuals (160 men and 126 women) were assayed using a ZL6000P blood viscosity analyzer (Beijing ZONCI Technology Development Co., China). The RIs of WBV were defined at 5 and 300 s-1 using a nonparametric percentile method, according to the CLSI EP28-A3 guideline.
Results: At 5 s-1, the median WBV (interquartile range, IQR) was 9.34 (8.54-10.29) millipascal-second (mPa·s) in the total population, 10.12 (9.33-10.54) mPa·s in men, and 8.53 (7.95-9.08) mPa·s in women. At 300 s-1, the median WBV (IQR) was 3.72 (3.45-4.00) mPa·s in the total population, 3.94 (3.74-4.10) mPa·s in men, and 3.42 (3.23-3.62) mPa·s in women. The WBV levels at 5 and 300 s-1 were significantly higher in men than in women (P<0.001). The 97.5th percentile upper reference limit (URL) for WBV at 5 s-1 was 11.32 mPa·s in the total population, 12.08 mPa·s in men, and 10.38 mPa·s in women. The 97.5th percentile URL for WBV at 300 s-1 was 4.47 mPa·s in the total population, 4.83 mPa·s in men, and 4.22 mPa·s in women.
Conclusions: This is the first study on the RIs of WBV using a cone-plate viscometer (ZL6000P blood viscosity analyzer) in Korea. We suggest that gender-specific RIs should be used for the Korean population.
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KEYWORD
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Reference interval, Whole blood viscosity, Cone-plate viscometer, Korean, ZL6000P blood viscosity analyzer
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