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KMID : 1100820210110040223
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Laboratory Medicine Online
2021 Volume.11 No. 4 p.223 ~ p.229
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Diagnostic Classification and Genomic Analyses of Cancer
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Kim Jong-Won
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Abstract
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Diagnostic classification of diseases is fundamental to disease diagnosis and treatment. Cancers have traditionally been classified based on histopathology, but cancer is defined as a genetic disease. Emerging genetic knowledge and genomic techniques applied to cancer are changing the diagnostic paradigm. Successes with targeted drug treatments such as Imatinib for chronic myeloid leukemia and Herceptin for breast cancer are accelerating the shift to the clinical genetic analysis of cancer. A recent cancer classification study using The Cancer Genome Atlas (TCGA) data yielded better performance than traditional histopathology. Eventually, genomic analysis will thoroughly reform cancer classification and diagnostic criteria.
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KEYWORD
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Cancer genomics, Cancer classification, Genomic analysis, Precision medicine
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