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KMID : 1100820220120010033
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Laboratory Medicine Online
2022 Volume.12 No. 1 p.33 ~ p.39
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Validation of Hematology Rapid Reporting System for Complete Blood Cell Count with Differential
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Lee Jung-Min
Yoon Soo-Young
Park Ji-Young
Kim Jee-Yong
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Abstract
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Background: Complete blood cell count (CBC) test, peripheral blood smears (PBS), and automatic hematology analyzers are used to screen patients with high-risk hematology malignancies. In this study, the workflow of urgent and routine samples and methods to improve the detection rate of blasts were evaluated. The purpose of this study was to validate the hematology rapid reporting system (HRS) for CBC and establish a strategy for the effective use of an automated hematology analyzer in clinical laboratories.
Methods: The flag performances of UniCel DxH 800 (Beckman Coulter, USA) and XE-2100 (Sysmex, Japan) systems used for blood tests were analyzed for urgent and routine samples. The results were compared with PBS results. Each test method’s sensitivity and specificity were determined to identify the most efficient blast detection method. In addition, receiver operating characteristic (ROC) curves of various parameters such as CBC and age were analyzed.
Results: The sensitivity and specificity of HRS were 66.80% and 99.85%, respectively, with urgent flags (four flags) and 92.95% and 98.49%, respectively, with routine flags (15 flags). The sensitivity of HRS for routine samples was significantly different from that for urgent samples (66.80% vs. 92.95%; P<0.0001), but no significant difference was observed in the specificity for HRS between routine and urgent samples (99.85% vs. 98.49%; P=1.00).
Conclusions: HRS using flags and blast history can be effectively used in clinical laboratories. HRS can be used as an effective reporting workflow for differential CBC in clinical laboratories.
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KEYWORD
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Automated hematology analyzer, Peripheral blood smear, Complete blood cell count
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