|
KMID : 1100820220120040310
|
|
Laboratory Medicine Online
2022 Volume.12 No. 4 p.310 ~ p.314
|
|
|
A Case Report of Passenger Lymphocyte Syndrome Following Bidirectional ABO-mismatched Kidney Transplantation
|
|
Kim Ji-Yeon
Song Jun-Hyup
Kwon Soon-Sung
Kim Sin-Young
Huh Kyu-Ha
Kim Hyun-Ok
|
|
|
Abstract
|
|
|
|
Passenger lymphocyte syndrome (PLS) is a subtype of graft-versus-host disease caused by the production of antibodies by transferred donor B-lymphocytes against red blood cells (RBCs) of the recipient. A 64-year-old male diagnosed with stage five chronic kidney disease underwent bidirectional ABO-mismatched kidney transplantation. The blood groups of the recipient and the donor were A+ and B+, respectively. After transplantation, hemoglobin (Hb) levels were eventually reduced to 6.3 g/dL on postoperative day (POD) 25. Elevated lactate dehydrogenase levels and positive direct antiglobulin test results indicated immune-mediated hemolysis as a possible cause of anemia. After switching RBC transfusion from type-A to type-O and conducting plasma exchange four times, on POD 35, Hb levels of the patient recovered up to 9.1 g/dL, and the patient was discharged from the hospital without complications. To the best of our knowledge, PLS in a bidirectional ABO-mismatched solid organ transplantation has been reported once in India, and this is the first case to be reported in Korea.
|
|
|
KEYWORD
|
|
|
ABO antibodies, Bidirectional ABO mismatch, Passenger lymphocyte syndrome, Kidney transplantation
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|