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KMID : 1100820230130010053
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Laboratory Medicine Online
2023 Volume.13 No. 1 p.53 ~ p.59
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Usefulness of Lymphocyte Subset Analysis Using Primary Immunodeficiency Orientation Tube Panel: Two Cases with Primary Immunodeficiency Diseases
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Ryu Seong-Eun
Shin Kyung-Hwa
Lee Hyun-Ji
Oh Seung-Hwan
Park Su-Eun
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Abstract
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Primary immunodeficiency diseases (PIDs) are a heterogeneous group of disorders caused by genetic defects in the immune system and exhibit a variety of clinical manifestations, including recurrent infections. Rapid and proper diagnosis is vital for proper therapeutic intervention. Compared to the conventional lymphocyte subset analysis, the standardized Primary Immunodeficiency Orientation Tube (PIDOT) panel has been proposed to provide a more detailed dissection of lymphocyte subsets according to their differentiation and maturation stages. This helps in screening of a suspected PID sample, and to provide quick guidance regarding further course of testing. Here, we report two cases of PID diagnosed by lymphocyte subset analysis using PIDOT panel to establish its usefulness in a clinical laboratory.
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KEYWORD
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Primary immunodeficiency disease, Severe combined immunodeficiency, Common variable immunodeficiency, Flow cytometry, Primary Immunodeficiency Orientation Tube
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