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KMID : 1100820230130020085
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Laboratory Medicine Online
2023 Volume.13 No. 2 p.85 ~ p.90
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Analysis of Positive Patterns and Follow-up Results of the QuantiFERON-TB Gold-Plus Test in the Screening of Patients and Healthcare Workers
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Shin Eun-Ju
Seo Jong-Do
Kim Han-Ah
Hur Mi-Na
Yun Yeo-Min
Moon Hee-Won
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Abstract
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Background: The early detection of latent tuberculosis infection is essential for reducing the incidence of tuberculosis (TB). The QuantiFERON-TB Gold-Plus (QFT-Plus; Qiagen, Germany) detects both CD8+ and CD4+ T-cell-mediated immune responses using TB1 and TB2 tubes. This study aimed to analyze the positive pattern and follow-up results of QFT-Plus when screening patients and healthcare workers (HCWs).
Methods: A total of 6,594 (4,765 patients and 1,829 HCWs) were tested using QFT-Plus from February 2019 to March 2022 at the Konkuk University Medical Center. We analyzed the positive rates and patterns in the two groups and divided them into subgroups based on the positive patterns (TB1-only, TB2-only, and TB1 and TB2) and the purpose of the test. Serial results were analyzed for each group.
Results: The positivity rates in the patients and HCWs were 16.0% and 1.4%, respectively. The single-tube positivity rate (TB1-only or TB2-only) was higher in HCWs than in patients (P=0.0035). Among the 83 subjects testing positive in the available serial QFT-Plus test results, all four HCWs showed reversion (positive to negative results). The reversion rate was highest in the TB2-only group (80%), and was significantly higher in the single-tube positive group than the both-tube (TB1 and TB2) positive group (53.3% vs. 19.1%, P=0.0061).
Conclusions: Subjects in the single-tube positive group, especially the TB2-only positive group, showed a higher reversion rate than subjects in the both-tube positive group. Further studies are needed to evaluate the clinical usefulness of TB2-only positivity in the QFT-Plus.
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KEYWORD
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QuantiFERON-TB Gold-Plus, Latent tuberculosis infection, Reversion
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