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KMID : 1100820230130040324
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Laboratory Medicine Online
2023 Volume.13 No. 4 p.324 ~ p.331
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Survey on the Implementation of Delta Checks and Panic Values in Immunoassays in Korea
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Lee Hye-Young
Shin Kyung-Hwa
Kim Soll-Ip
Yoo Soo-Jin
Yu Shin-Ae
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Abstract
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Background : This study aimed to inquire about the implementation of delta checks and panic values for immunoassays in clinical laboratories through an online survey.
Methods : A questionnaire survey was conducted on laboratory medicine specialists working in laboratories that perform five tumor markers, including alpha-fetoprotein, cancer antigen 125, cancer antigen 19-9 (CA19-9), carcinoembryonic antigen, and prostate-specific antigen (PSA), and thyroid function tests, including triiodothyronine, free thyroxine (T4), and thyroid-stimulating hormone.
Results : A total of 87 institutions responded to the questionnaire, and 75 laboratories (86.2%) were performing all 8 tests. The delta check was most used in the PSA test (38.8%, 33/85) and less used in CA19-9 (34.1%, 28/82). The delta percent change (DPC) formula was the most commonly used (65.6?92.6%). The criteria of DPC varied from 4.5 to 200%, and the most common was 50%, followed by 20%. Approximately 50% of laboratories using DPC did not use time intervals, and some laboratories used time limits as 1, 3, 6, or 12 months. The panic checks were most performed in CA19-9 test (51.2%, 42/82) and less performed in free T4 (36.0%, 31/86). The criteria for the panic value were mainly established based on the in-house laboratory data or data provided by reagent companies.
Conclusions : Many laboratories do not apply delta or panic checks in immunoassays. Further research on the suitable delta check criteria and panic values for the assay and patient characteristics is needed.
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KEYWORD
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Immunoassay, Delta check, Survey, Tumor marker, Thyroid function test
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