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KMID : 1100820240140010017
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Laboratory Medicine Online
2024 Volume.14 No. 1 p.17 ~ p.23
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Comparative Evaluation of Creatinine Interferences by Glucose in Various Dialysates Based on Creatinine Measurement Methods
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Jeon Bo-Hyun
Rim John-Hoon
Lim Jong-Baek
Park Yong-Jung
Lee Jung-Eun
Kim Beom-Seok
Park Hyeong-Cheon
Kim Jeong-Ho
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Abstract
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Background: The peritoneal equilibrium test (PET), a semi-quantitative assessment for peritoneal dialysis patients, helps evaluate suitability, prognosis, and modality changes. High glucose concentrations in peritoneal dialysates (PD) can interfere with creatinine assays, necessitating a correction factor (CF). We calculated the CF for various PD and creatinine measurement methods.
Methods: Creatinine and glucose levels in the PD from three manufacturers were determined using five systems of measurement principles and analyzers. New CFs were calculated using method A (Twardowski) or B (linear regression). We retrospectively evaluated the equivalence of the 204 PET semiquantitative transfer results obtained over two years using the new and old CFs.
Results: The calculated CF of method A ranged from 0.000051183 to 0.000221729, depending on the type of PD and creatinine measurement system. The CF of method B had a slope ranging from 0.000106270 to 0.000285902 and an intercept ranging from -0.248825054 to -0.08519815 for each combination. We found very good agreement between the PET results obtained by applying the new CFs and those obtained by applying the old CFs (weighted kappa=0.95) with method A and a substantial agreement (weighted kappa=0.82) with method B, with variations according to the systems.
Conclusions: The CF of PD differed according to the creatinine measurement systems and PD types. Although there was good agreement in PET results between new and old CFs, we propose the application of the new calculated CFs with the new creatinine measurement method because some cases showed less agreement.
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KEYWORD
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Peritoneal equilibrium test, Creatinine, Correction factor
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