|
KMID : 1101620170280030099
|
|
Perinatology
2017 Volume.28 No. 3 p.99 ~ p.102
|
|
|
Intra-Amniotic Candida Infection Treated by Liposomal Amphotericin B in a Patient with Cervical Insufficiency
|
|
Kang Hye-Sim
Yang Sun-Hye
Kim Hee-Sun
Park Jeong-Woo
|
|
|
Abstract
|
|
|
|
Intra-amniotic Candida infection is uncommon but the consequence can be catastrophic. Transcervical amphotericin B and intra-amniotic fluconazole administration were identified in the literature. We present a case with intact membranes and ongoing pregnancy treated by maternal intravenous liposomal amphotericin B. A primipara who underwent cerclage placement before fetal viability was diagnosed with intra-amniotic Candida infection. Although maternal intravenous liposomal amphotericin B eradicated fungi in the amniotic cavity, Escherichia coli invasion caused devastating chorioamnionitis. The newborn delivered at 27+3 weeks' gestation did not survive due to respiratory distress syndrome and sepsis. Despite negative conversion of intra-amniotic culture results for fungi after treatment, another pathogen such as bacteria could ascend into the amniotic cavity via weakened membranes. Clinicians should consider broad-spectrum antibiotics as well as antifungal agents in this setting.
|
|
|
KEYWORD
|
|
|
Amniotic fluid, Infection, Candida albicans, Liposomal amphotericin B, Uterine cervical insufficiency
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|