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KMID : 1101620190300010014
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Perinatology
2019 Volume.30 No. 1 p.14 ~ p.19
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Risk Factors for Nephrocalcinosis in Very Low Birth Weight Infants
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Han Sang-Eun
Cha Tea-Hyen
Kim Jin-Sup
Kim Chang-Ryul
Park Hyun-Kyung
Lee Hyun-Ju
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Abstract
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Objective: The objective was to identify risk factors for nephrocalcinosis in very low birth weight (VLBW) infants.
Methods: Prospective study has done between 2014 and 2017. The study included 81 VLBW infants in the neonatal intensive care unit (NICU). Renal ultrasonography was performed at four weeks and 3 months. Baseline characteristics, complications and medication during NICU admission were collected. 25-(OH)-vitamin D, calcium, phosphorous, alkaline phosphatase, urine calcium to creatinine ratio were serially measured.
Results: The incidence of nephrocalcinosis was 16.9%. On univariate analysis, gestational age, lower birth weight, maternal pregnancy-induced hypertension, neonatal sepsis, and frequency of vancomycin and caffeine citrate treatment were significantly associated with nephrocalcinosis. In addition, preterm infants with nephrocalcinosis had lower cord blood 25-(OH)-vitamin D and serum calcium levels and higher serum alkaline phosphatase levels at 2 weeks of life. Multivariate analysis showed that gestational age (P=0.042), birth weight (P=0.019), sepsis (P=0.046), small for gestational age (P=0.015), and maternal pregnancy-induced hypertension (P=0.024) were significant risk factors for nephrocalcinosis.
Conclusion: This study suggests that neonatal sepsis and maternal pregnancy-induced hypertension, in addition to gestational age and birth weight are important perinatal risk factors for nephrocalcinosis.
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KEYWORD
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Nephrocalcinosis, Prematurity, Very low birth weight, Risk factors
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