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KMID : 1101620210320030105
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Perinatology
2021 Volume.32 No. 3 p.105 ~ p.110
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Mesenchymal Stem Cell Therapy for Intractable Neonatal Disorders
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Ahn So-Yoon
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Abstract
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Mesenchymal stem cell (MSC) transplantation has generated great interest as a new promising therapeutic strategy for the next generation therapy of intractable and devastating newborn disorders with complex multifactorial etiologies, including bronchopulmonary dysplasia (BPD), intraventricular hemorrhage (IVH), and hypoxic-ischemic encephalopathy (HIE). In the disease environment of active inflammatory and noxious stimuli, MSCs have been believed to excrete multiple secretomes those may play restorative actions, including anti-inflammatory, anti-oxidative, anti-apoptotic, and anti-fibrotic actions, to promote the recovery of injury tissue. In this review, recent progress in stem cell research for the treatment of neonatal BPD, IVH and HIE, was introduced with preclinical and clinical data.
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KEYWORD
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Infant, Newborn, Mesenchymal stem cells, Mesenchymal stem cell transplantation, Clinical trial
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