|
KMID : 1101620220330040188
|
|
Perinatology
2022 Volume.33 No. 4 p.188 ~ p.195
|
|
|
The Association between Qualitative Fetal Fibronectin Test from Cervicovaginal Discharge and the Presence of Histologic Chorioamnionitis in Preterm Labor with Intact Membranes
|
|
Kim Hyun-Ji
Lee Suk-Jeong
Shin Ha-Lim
Lee Hyun-Kyoung
Hong Su-Been
Kim Hyeon-Ji
Park Jee-Yoon
|
|
|
Abstract
|
|
|
Objective: To determine the predictive value of the qualitative fetal fibronectin test from cervicovaginal discharge for histologic chorioamnionitis in patients with preterm labor and intact membranes
Methods: This retrospective cohort study included consecutive singleton pregnancies who had been hospitalized for uterine contractions before 37 weeks of gestation from August 2017 to May 2020. All patients underwent the qualitative fetal fibronectin test from cervicovaginal discharge, cervical length measurement by transvaginal ultrasonography, and blood test for C-reactive protein. Those who delivered at term gestation were excluded for the analysis. The primary outcome was the presence of histologic chorioamnionitis.
Results: (1) The proportion of histologic chorioamnionitis was higher in the group with positive fetal fibronectin results than that with negative results (62% vs. 18%, P<0.001); (2) The positive fetal fibronectin was significantly associated with histologic chorioamnionitis (relative risk 4.6, 95% confidence interval 1.3-16.0, P=0.017) in multivariate logistic regression analysis even after adjustment of gestational age at delivery; (3) The sensitivity to predict histologic chorioamnionitis of qualitative positive fetal fibronectin test was 87%.
Conclusion: The qualitative fetal fibronectin test from cervicovaginal discharge is independently associated with the presence of histologic chorioamnionitis.
|
|
|
KEYWORD
|
|
|
Fibronectin, Chorioamnionitis, Premature birth, Premature labor, Cervical length
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|