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KMID : 1104820130010020095
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Journal of Digestive Cancer Research
2013 Volume.1 No. 2 p.95 ~ p.99
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Stool-based MicroRNA for Early Diagnosis of Colorectal Cancer
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Choi Ji-Hye
Cho Young-Seok
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Abstract
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MicroRNA (miRNA) dysregulations are associated with various types of human cancers, and miRNAs can function as tumor suppressors and oncogenes. Emerging evidence has shown that miRNA pathway is also altered during colorectal tumorigenesis. The detection of cancer-related miRNAs in stool samples may become useful diagnostic marker for colorectal cancer, because miRNAs in stool samples has high stability, and maintains a high portion of its original level. Recent studies reported that stool-based miRNAs can offer more sensitivity and specificity than currently used stool-based screening methods for CRC. In addition, unlike fecal occult blood test, sampling on consecutive dates and special dietary restrictions are not required. In this review, the authors discuss stoolbased miRNA for the early diagnosis of CRC and perspectives on future application.
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KEYWORD
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Colorectal cancer, Diagnosis, Early detection of Cancer, MicroRNAs, Feces
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