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KMID : 1104820160040010043
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Journal of Digestive Cancer Research
2016 Volume.4 No. 1 p.43 ~ p.45
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A Case of Therapy-related Myelodysplastic Syndrome after FOLFOX4 Chemotherapy in Advanced Gastric Cancer
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Seo Kwang-Il
Kim Sung-Eun
Park Moo-In
Park Seun-Ja
Moon Won
Han You-Jin
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Abstract
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Oxaliplatin is a third-generation platinum compound widely used to treat gastrointestinal malignancy. One of the major side effects of oxaliplatin is thrombocytopenia, the development of which can limit appropriate treatment. We report a 38-year-old man with advanced gastric cancer who developed severe thrombocytopenia after FOLFOX4 (oxaliplatin, leucovorin, and fluorouracil) chemotherapy. The thrombocytopenia was associated with therapy-related myelodysplastic syndrome after cytotoxic chemotherapy and was confirmed by bone marrow biopsy and genetic study. Therefore, physicians should be aware of therapy-related hematologic complications, especially with an oxaliplatin-based chemoregimen, and might consider the bone marrow study in those patients.
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KEYWORD
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Gastric cancer, Oxaliplatin, Myelodysplastic syndrome, Side effect
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