|
KMID : 1104820170050010058
|
|
Journal of Digestive Cancer Research
2017 Volume.5 No. 1 p.58 ~ p.61
|
|
|
A Case of Coronary Vasospasm in a Patient with Esophageal Cancer Receiving Chemotherapy with 5-fluorouracil
|
|
Lee Jin-Wook
Park Moo-In
Park Seun-Ja
Moon Won
Kim Sung-Eun
Kim Jae-Hyun
Jung Kyoung-Won
|
|
|
Abstract
|
|
|
|
5-Fluorouracil (5-FU) has been widely used in the treatment of various solid tumors. However, 5-FU cardiotoxicity is being reported with increasing frequency. The main symptom of cardiotoxicity is chest pain at rest with ischemic electrocardiographic changes. Up until now, the underlying mechanism has been suspected to be coronary artery spasm. However, this chest pain associated with 5-FU has several characteristics that are incompatible with coronary artery spasm; eg, inefficacy of calcium-channel blocker and a slow increase in cardiac enzyme levels. We experienced a case of 5-FU-induced cardiotoxicity which showed clinical findings consistent with acute myocardial infarction. Based on the clinical findings, coronary angiography, and no stenosis was noted. However, we concluded that the cardiotoxicity in this case was due to ischemia caused by coronary artery spasm. Because vasodilatator was effective and secondary attack was followed.
|
|
|
KEYWORD
|
|
|
Fluorouracil, Esophageal cancer, Coronary vasospasm
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|