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KMID : 1104820170050010062
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Journal of Digestive Cancer Research
2017 Volume.5 No. 1 p.62 ~ p.65
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A Case of Gemcitabine Plus Nanoparticle Albumin Bound (nab)-paclitaxel Induced Cardiotoxicity in Patient of Metastatic Pancreatic Cancer
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Kim Mi-Kang
Park Se-Woo
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Abstract
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Pancreatic cancer is an aggressive disease and despite the efforts of the past few decades, the 5-year overall survival (OS) rate remains disappointing and does not exceed 10% in Korea. Especially, only 15-20% of patients are candidates for surgical resection because most patients are diagnosed with locally advanced or metastatic disease, and their only treatment approach is palliative chemotherapy. Since the first chemo-regimen of Gemcitabine and Nanoparticle albumin bound (nab) ― paclitaxel was brought to clinical practice in 2013, the improvement in overall survival, progression- free survival, and response rate was achieved in patients with metastatic pancreatic adenocarcinoma. We report the case of a young patient with cardiogenic shock accompanied by multi-organ failure after 4th cycle Gemcitabine and nab-paclitaxel chemotherapy with partial response.
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KEYWORD
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Gemcitabine, Nanoparticle albumin bound (nab)-Paclitaxel, Pancreatic cancer, Cardiotoxicity
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