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KMID : 1104820170050020086
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Journal of Digestive Cancer Research
2017 Volume.5 No. 2 p.86 ~ p.90
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Type 3 Gastric Neuroendocrine Neoplasm Clinical Features: A Multicenter Study in Korea
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Lee Kyong-Joo
Kim Hee-Man
Lee Sang-Kil
Choi Ho-Sun
Kim Jie-Hyun
Park Seun-Ja
Park Sung-Chul
Jang Byung-Ik
Jung Jin-Tae
Jeon Tae-Joo
Lee Jong-Hun
Sung Jae-Kyu
Park Se-Mi
Kim Yoon-Jae
Cho Jae-Hee
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Abstract
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Background: The aim of this study was to investigate clinicopathologic features of type 3 gastric neuroendocrine neoplasm (NEN) by treatment modality.
Methods: The Korean Society of Gastrointestinal Cancer conducted the Korean Gastroenteropancreatic Neuroendocrine Tumor Registry, a retrospective registry database of gastroenteropancreatic neuroendocrine tumors from 16 hospitals in Korea. The normal serum gastrin level range was defined as <100 pg/mL, and gastric NEN patients with normal gastrin level were selected for analysis.
Results: Among 358 patients with gastric NEN, 21 (5.9%) patients were classified with type 3 gastric NEN. The median age was 53 years (range 30-74). According to the WHO 2010 classification, 13 (61.9%) patients had grade 1, and 8 (38.1%) patients had grade 2 or 3. Endoscopic treatment was performed in 14 (66.7%) patients, and surgery was performed in 7 (33.3%) patients. The tumor size was smaller in the endoscopic treatment group than in the surgery group (0.6 cm vs 1.3 cm, p=0.006). After treatment, there was one recurrence in the surgery group.
Conclusion: In small size Type 3 gastric NEN, endoscopic treatment was associated with a good prognosis, compared to surgery. Thus, endoscopic treatment can be used an alternative modality in selected cases of type 3 gastric NEN.
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KEYWORD
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Stomach, Neuroendocrine neoplasm, Type 3, Endoscopic resection, Surgery
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