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KMID : 1104820170050020091
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Journal of Digestive Cancer Research
2017 Volume.5 No. 2 p.91 ~ p.96
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The Maximum Standardized Uptake Value of 18F-FDG PET/CT in Diabetic Patients with Metastatic Pancreatic Ductal Adenocarcinoma
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Paik Kyu-Hyun
Kim Hyoung-Woo
Lee Jong-Chan
Kang Jin-Gu
Lee Yoon-Suk
Kim Jai-Hwan
Hwang Jin-Hyeok
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Abstract
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Background: To evaluate whether DM affects the SUVmax of metastatic lesions on 18F-FDG PET/CT and whether the SUVmax can influence the prognosis of metastatic PDAC patients.
Methods: We conducted a retrospective study of 86 patients with metastatic PDAC who underwent PET/CT before treatment. The SUVmax of primary and metastatic lesions and the ratios of the SUVmax were measured. Long-term survival was evaluated using clinical parameters.
Results: The mean SUVmax of primary lesion was lower in the DM group than in the non-DM group (4.74 vs. 5.96, p=0.009). The SUVmax for all metastatic lesions, except those in the lung, were lower in the DM group than in the non- DM group, and these differences were statistically significant in the lymph nodes and peritoneum. In the 35 patients with hepatic metastasis, higher ratios of the liver SUVmax significantly correlated with shorter OS (HR, 2.625; p=0.013).
Conclusion: DM can influence the lower SUVmax of metastatic lesions as well as primary lesions. The SUVmax ratio of hepatic metastasis could influence on prognosis in metastatic PDAC patients.
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KEYWORD
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Pancreatic ductal adenocarcinoma, Metastasis, PET-CT, Diabetes mellitus
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