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KMID : 1104820170050020125
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Journal of Digestive Cancer Research
2017 Volume.5 No. 2 p.125 ~ p.129
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A Case of Partial Response with Trastuzumab Based Treatment in Advanced Gastric Cancer with Multiple Metastasis
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Lee Seo-Hee
Jeong Hyun-Yong
Moon Hee-Seok
Sung Jae-Kyu
Kang Sun-Hyung
Kim Ju-Seok
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Abstract
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A 38-year-old man presented with abdominal discomfort and was diagnosed as type 3 advanced gastric cancer with multiple liver and lung metastases (Stage IV). Endoscopic forcep biopsy revealed moderately differentiated adenocarcinoma, which stained positive HER2 (Human epidermal growth factor receptor) on immunohistochemistry. We started chemotherapy with FP (5-Fluorouracil plus Cisplatin) plus trastuzumab. After 6 cycles of FP plus trastuzumab chemotherapy, there were partial response in the liver, lung and lymph nodes metastasis. Especially, metastatic lung lesions showed remarkable improvement. Chemotherapy with FP plus trastuzamab was effective for HER2 positive advanced cancer with multiple liver and lung metastases. Through active research on target therapy about advanced gastric cancer, we expect to improve the survival rate and quality of life of patients with advanced gastric cancer who can not undergo curative resection.
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KEYWORD
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Advanced gastric cancer, HER2, Target therapy, Trastuzumab
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