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KMID : 1104820180060010040
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Journal of Digestive Cancer Research
2018 Volume.6 No. 1 p.40 ~ p.44
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A Case of Complete Response with FOLFOX Based Neo-adjuvant Chemotherapy in Advanced Gastric Cancer with Lymph Node Metastasis
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Kim Myung-Hee
Jeong Hyun-Yong
Moon Hee-Seok
Sung Jae-Kyu
Kang Sun-Hyung
Kim Ju-Seok
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Abstract
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A 77-year-old man presented with abdominal discomfort and was diagnosed as Borrmann type 3 advanced gastric cancer with multiple lymph node metastases. An abdominal computed tomography (CT) and positron emission tomography-computed tomography (PET-CT) showed AGC, clinical stage IIIC (T4aN3M0). We started neo-adjuvant chemotherapy with FOLFOX (5-fluorouracil (5-FU))+Leucovorin+Oxaliplatin). After 3 cycles of FOLFOX chemotherapy, follow-up endoscopy showed remarkable improvement. Primary lesion and metastatic lymph nodes decreased size on follow up computed tomography (CT). The patient underwent radical total gastrectomy with esophagojejunostomy and histopathology revealed no remnant malignant cells at previous primary cancer lesion. The patient has currently completed his 3 cycle of adjuvant chemotherapy without recurrence. After an abdominal CT response assessment, further course of therapy will be decided.
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KEYWORD
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Advanced gastric cancer, Neo-adjuvant chemotherapy, Complete remission
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