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KMID : 1104820190070010022
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Journal of Digestive Cancer Research
2019 Volume.7 No. 1 p.22 ~ p.25
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Extraordinary Response of Metastatic Pancreatic Cancer to Chemotherapy
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Shin Dong-Woo
Kim Jin-Kook
Lee Jong-Chan
Kim Jai-Hwan
Hwang Jin-Hyeok
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Abstract
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A 58-year-old woman presented with right flank and back pain for one month. After undergoing an abdominal computed tomography (CT), she was referred to our hospital. The abdominal CT showed a hypodense pancreatic tail mass with multiple retroperitoneal lymph node metastases. Positron emission tomography-computed tomography (PET-CT) scan showed high 18F-FDG uptake in pancreatic tumor and enlarged lymph nodes. Endoscopic ultrasound fine needle aspiration (EUS-FNA) revealed adenocarcinoma, which stained strongly in hENT1 (human equilibrative nucleoside transporter 1) on immunohistochemistry. She received gemcitabine 1,000 mg/m2 + nanoparticle albumin-bound paclitaxel 125 mg/m2 as a palliative chemotherapy. Follow-up abdominal CT and PET-CT after 4 cycles of chemotherapy showed that both pancreatic mass and the metastatic retroperitoneal lymph nodes were nearly disappeared. We report a case of 58-year-old female with metastatic pancreatic cancer who had a dramatic response to palliative chemotherapy (gemcitabine plus nanoparticle albumin-bound paclitaxel).
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KEYWORD
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Metastatic pancreatic cancer, Gemcitabine, Nanoparticle albumin-bound paclitaxel, hENT1 immunohistochemical stain
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