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KMID : 1118520080050040244
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Psychiatry Investigation
2008 Volume.5 No. 4 p.244 ~ p.246
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Association Study of a Serotonin Receptor 2A Gene -1438A/G Polymorphism and Anxiety-Related Traits
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Kim Kye-Hyun
Woo Hee-Yeon
Lim Se-Won
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Abstract
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Objective: The aim of this study was to investigate the relationship between the ?1438 A/G polymorphism of serotonin receptor 2A (5HTR2A) and anxiety-related traits in Korean adolescent females.
Methods: A total of 174 Korean adolescent females were tested for the -1438A/G polymorphism of 5HTR2A using polymerase chain reaction (PCR)-based methods. Anxietyrelated traits were evaluated using the Anxiety Sensitivity Index (ASI) and the trait form of the Spielberg State-Trait Anxiety Inventory (T-STAI).
Results: There was no difference between the genotypes with respect to scores pertaining to anxiety-related traits. Although the G allele carriers (GG or AG genotype) scored lower on the psychological subscale of the ASI (4.76±3.00 vs 5.98±4.00, p=0.038), this difference was not significant after Bonferroni correction.
Conslusions: These findings suggest that the -1438A/G polymorphism of 5HTR2A might not be associated with anxiety sensitivity or trait anxiety.
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KEYWORD
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Anxiety, Anxiety sensitivity, Polymorphism, Serotonin 2A receptor.
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