|
KMID : 1118520100070040285
|
|
Psychiatry Investigation
2010 Volume.7 No. 4 p.285 ~ p.290
|
|
|
Gender-Specific Association of the Brain-Derived Neurotrophic Factor Gene with Attention-Deficit/Hyperactivity Disorder
|
|
Cho Soo-Churl
Kim Hyo-Won
Kim Boong-Nyun
Kim Jae-Won
Shin Min-Sup
Chung Seock-Hoon
Jung Sun-Woo
Yoo Hee-Jeong
Chung In-Won
Chung Un-Sun
Son Jung-Woo
|
|
|
Abstract
|
|
|
Objective: Attention-deficit/hyperactivity disorder (ADHD) is a complex neurodevelopmental disorder with a strong genetic component. Brain-derived neurotrophic factor (BDNF), which participates in the differentiation and survival of dopaminergic and noradrenergic neurons, could play a role in ADHD development. We aimed to explore the relationships between ADHD and BDNF gene polymorphism.
Methods: We conducted a case-control analysis of 202 ADHD subjects and 159 controls, performed a transmission disequilibrium test on 151 trios, and compared the results of a continuous performance test (CPT) according to the genotype of the three single nucleotide polymorphisms (rs11030101, rs6265, rs16917204) in the BDNF gene.
Results: In the case-control analysis, the AA genotype of the BDNF rs11030101 polymorphism was significantly associated with ADHD only in girls (p=0.024, odds ratio=3.00). The T-G-G haplotype was significantly less frequent (p=0.005) and A-G-G was more frequent (p=0.048) in girls with ADHD than in control girls (global p=0.027). A multivariate analysis of variance for commission errors on the CPT showed a significant main effect for the rs11030101 genotype (p=0.026) and an interaction effect of the rs11030101 genotype and gender (p=0.032) in ADHD probands.
Conclusion: These results provide preliminary evidence for a gender-specific association between BDNF and ADHD in the Korean population.
|
|
|
KEYWORD
|
|
|
Association studies, Attention-deficit/hyperactivity disorder, Brain-derived neurotrophic factor, Continuous performance test, Single nucleotide polymorphism
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|