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KMID : 1118520110080030207
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Psychiatry Investigation
2011 Volume.8 No. 3 p.207 ~ p.213
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Effect of Initial Ziprasidone Dose on Treatment Outcome of Korean Patients with Acute Manic or Mixed Episodes
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Woo Young-Sup
Bahk Won-Myong
Jo Soo-Hyun
Yoon Bo-Hyun
Lee Jung-Goo
Kim Won
Jeong Jong-Hyun
Seo Jeong-Seok
Min Kyung-Joon
Jon Duk-In
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Abstract
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Objective: We investigated the efficacy and tolerability of ziprasidone combined with divalproex to determine the relationship between the initial dose of ziprasidone and the treatment effect among Korean patients with acute bipolar manic or mixed disorders.
Methods: This study was a 6-week, open-label, prospective investigation of Korean patients with an acute manic or mixed episode of bipolar disorder. Sixty-five patients were recruited. The patients were categorized based on the initial dose of ziprasidone as follows: low (20-79 mg/day) and standard (80 mg/day). Ziprasidone was given in combination with divalproex in flexible doses, according to the clinical response and tolerability.
Results: The response and remission rates were significantly higher in the standard-dose group than the low-dose group. The combination of ziprasidone and divalproex was well-tolerated and adverse events were mostly mild with no statistically significant increase in body weight.
Conclusion: The results of this study showed that a standard starting dose of ziprasidone in combination with divalproex for bipolar disorder is more effective than a low starting dose.
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KEYWORD
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Bipolar disorder, Divalproex, Initial dose, Manic episode, Ziprasidone
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