KMID : 1118520110080030234
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Psychiatry Investigation 2011 Volume.8 No. 3 p.234 ~ p.244
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Antidepressant Prescribing Patterns in Korea: Results from the Clinical Research Center for Depression Study
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Bae Kyung-Yeol
Kim Sung-Wan Kim Jae-Min Shin Il-Seon Yoon Jin-Sang Jung Sung-Won Lee Min-Soo Yim Hyeon-Woo Jun Tae-Youn
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Abstract
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Objective: This study aimed to investigate antidepressant prescribing patterns, including initial choice, switching and combining, and concomitant use of non-antidepressant agents, for depressive disorders in naturalistic clinical care settings in Korea.
Methods: Patients with depressive disorder were recruited from both outpatient and inpatient settings in 18 hospitals from all over Korea. Treatment was performed in naturalistic patterns based on each clinician¡¯s decision. Data were collected on the prescription of antidepressants and concomitant agents from baseline to 12-week follow-up.
Results: Selective serotonin reuptake inhibitors (SSRIs) were the most commonly prescribed initial antidepressant (48.9%), followed by newer dual-action antidepressants (45.8%). When an SSRI was the initial antidepressant, 46.2% of patients whose medication was changed were moved to newer dual-action antidepressants, and 67.4% of combination cases were combined with newer dual-action ones. When a newer dual-action antidepressant was the initial antidepressant, 70.6% of patients whose medication was changed were moved to SSRIs, and other antidepressants including tricyclic antidepressants were most commonly added for combination treatment (50% of combination cases). During the treatment period, 20.6% of antidepressants prescribed were augmented by non-antidepressant agents, and 75.1% were used concomitantly with anxiolytics or hypnotics. The most commonly used concomitant non-antidepressant agent was quetiapine.
Conclusion: The selection of antidepressants and the concomitant use of non-antidepressant agents are becoming increasingly diversified, and the results of this study reflect changes in the prescribing pattern in actual Korean practices.
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KEYWORD
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Antidepressive agents, Depression, Prescriptions, Korea, CRESCEND
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