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KMID : 1118520120090040384
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Psychiatry Investigation
2012 Volume.9 No. 4 p.384 ~ p.390
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Effect of Methylphenidate on Sleep Parameters in Children with ADHD
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Lee Sang-Heon
Seo Wan-Seok
Sung Hyung-Mo
Choi Tae-Young
Kim So-Yeun
Choi So-Jeong
Koo Bon-Hoon
Lee Jong-Hun
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Abstract
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Objective: The primary aim of this study was to investigate the acute impact of methylphenidate (MPH) on sleep parameters in attention-deficit/hyperactivity disorder (ADHD) children. The second aim was to investigate the different effects of intermediate- and long-acting MPH on sleep parameters. The third aim was to test the different effects of dose and age on sleep parameters.
Methods: Ninety-three ADHD children were enrolled and randomized to two different MPH preparations. Baseline and daily sleep diaries were evaluated for four weeks after taking medication. Weekday and weekend bedtimes, wake-up times, sleep latencies and total sleep times were compared by weeks.
Results: After taking MPH, there was a significant delay in bedtimes and a significant reduction of total sleep time (TST) both on weekdays and at weekends. There was also a significant delay in wake-up time on weekdays. However, the difference was applied to younger age group children only. There was no difference in changes of TST between metadate-CD and OROS-MPH. There also was no difference in changes of TST with different doses of MPH.
Conclusion: MPH had negative impacts on sleep among young ADHD children, but different preparations and doses did not affect the result.
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KEYWORD
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ADHD, Children, Methylphenidate, OROS-MPH, Metadate-CD
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