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KMID : 1118520130100020180
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Psychiatry Investigation
2013 Volume.10 No. 2 p.180 ~ p.189
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No Effect of Serotoninergic Gene Variants on Response to Interpersonal Counseling and Antidepressants in Major Depression
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Serretti Alessandro
Fabbri Chiara
Pellegrini Silvia
Porcelli Stefano
Politi Pierluigi
Bellino Silvio
Menchetti Marco
Mariotti Veronica
Demi Cristina
Martinelli Valentina
Cappucciati Marco
Bozzatello Paola
Brignolo Elena
Brambilla Paolo
Pae Chi-Un
Balestrieri Matteo
Ronchi Diana De
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Abstract
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Objective: Gene variants within the serotonin pathway have been associated with major depressive disorder (MDD) treatment outcomes, however a possible different modulation on pharmacological or psychological treatments has never been investigated.
Methods: One hundred sixty MDD patients were partially randomized to either inter-personal counseling (IPC) or antidepressants. The primary outcome was remission at week 8. Five serotonergic polymorphisms were investigated (COMT rs4680, HTR1A rs6295, HTR2A rs2224721, HTR2A rs7997012 and SLC6A4 rs421417).
Results: IPC (n=43) and antidepressant (n=117) treated patients did not show any difference in remission rates at week 8 (corrected for baseline severity, age and center). None of the studied gene variants impacted on response and remission rates at week 8 neither in the IPC nor in the antidepressant group. An analysis of the whole sample showed a trend of association between rs7997012 AA genotype and a better treatment outcome.
Conclusion: Our study confirms that IPC is an effective psychological intervention comparable to antidepressants in mild-moderate MDD. Polymorphisms related to the serotonin system did not exert a major effect on clinical outcomes in none of the treatment groups.
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KEYWORD
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Antidepressants, Psychotherapy, 5-HT, 5-HT1A receptor, 5-HT2A receptor, Serotonin transporter, COMT, Genes, Polymorphism, Major depression
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