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KMID : 1118520140110040476
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Psychiatry Investigation
2014 Volume.11 No. 4 p.476 ~ p.480
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Association of SNAP-25 Gene Dde l and Mnl l Polymorphisms with Adult Attention Deficit Hyperactivity Disorder
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Herken Hasan
Erdal Mehmet Emin
Kenar Ayse Nur Inci
Unal Gonca Ayse
Cakaloz Burcu
Ay Mustafa Ertan
Yucel Erinc
Edgunlu Tuba
Sengul Cem
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Abstract
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Objective : The synaptosomal-associated protein of 25 kDa (SNAP-25) gene is a presynaptic plasma membrane protein and an integral component of the vesicle docking and fusion machinery mediating secretion of neurotransmitters. Previously, several studies reported association between SNAP-25 and attention deficit hyperactivity disorder (ADHD). We investigated whether these SNAP-25 polymorphisms (MnlI T/G and DdelI T/C) were also associated with ADHD in the Turkish population.
Methods : Our study comprised unrelated 139 subjects who met DSM-IV criteria for ADHD and 73 controls and all were of Turkish origin. Genetic analyses were performed and patients were evaluated with Wender-Utah Rating Scale and Adult ADD/ADHD DSM IV-Based Diagnostic Screening and Rating Scale.
Results : SNAP-25 DdelI polymorphism was not associated with ADHD but there was a statistically significant difference between ADHD patients and controls for SNAP-25 MnlI polymorphism. For SNAP-25 MnlI polymorphism patients with G/G genotype of the SNAP-25 gene MnlI polymorphism had higher Wender-Utah scores and higher scores in the 1st and 3rd parts of adult ADD/ADHD Scale.
Conclusion : We detected a significant association of the MnlI polymorphism in our ADHD sample which was similar to previous findings. Our study also revealed that SNAP-25 MnlI polymorphism was also associated with symptom severity of ADHD. This study is also, the first report on the association of SNAP-25 with ADHD in the Turkish population.
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KEYWORD
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ADHD, SNAP-25 gene, Genetic
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