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KMID : 1118520150120010136
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Psychiatry Investigation
2015 Volume.12 No. 1 p.136 ~ p.141
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Possible Association between Serotonin Transporter Gene Polymorphism and Suicide Behavior in Major Depressive Disorder
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Lee Hwa-Young
Hong Jin-Pyo
Hwang Jung-A
Lee Heon-Jeong
Yoon Ho-Kyung
Lee Bun-Hee
Kim Yong-Ku
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Abstract
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Objective : The serotonin transporter (5-HTT) genes are major candidate genes for modulating the suicidal behavior. We investigated the association between serotonin transporter polymorphisms and suicidal behavior in patients with major depressive disorder (MDD).
Methods : Serotonin transporter intron 2 VNTR polymorphism (5-HTTVNTR) and serotonin transporter linked polymorphic region polymorphism (5-HTTLPR) were analyzed in 132 depressed patients with suicidal attempt as well as in 122 normal controls. Hamilton's 17-item Depression Rating Scale (HDRS), the Risk-Rescue rating system (RRR) and the Lethality Suicide Attempt Rating Scale updated (LSARS-II) were assessed for the depressed patients.
Results : Although not statistically significant, a trend was found such that the 10/10 and 10/12 alleles of 5-HTTVNTR were more common in suicidal subjects than in control subjects. Comparing allele frequency, those with a 10 allele or 10 allele carriers were higher in suicidal subjects than in control subjects. No difference was noted in 5-HTTLPR genotypes and haplotype distribution between the suicidal subjects and control subjects. The RRR scores in subjects with the 10/10 5-HTTVNTR genotype or 10 5-HTTVNTR allele were significantly lower than those in subjects with other genotypes.
Conclusion : These results show the possibility that 10 allele of 5-HTTVNTR is related to suicidal behavior in the suicidal subjects with MDD and suggest that 12 allele of 5-HTTVNTR might be related to more lethality in the suicidal subjects with MDD.
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KEYWORD
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Serotonin transporter, Polymorphism, Haplotype, Suicide, Major depressive disorder.
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