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KMID : 1118520160130030265
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Psychiatry Investigation
2016 Volume.13 No. 3 p.265 ~ p.276
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Review of Cohort Studies for Mood Disorders
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Jeon Hong-Jin
Baek Ji-Hyun
Ahn Yong-Min
Kim Se-Joo
Ha Tae-Hyun
Cha Bo-Seok
Moon Eun-Soo
Kang Hee-Ju
Ryu Vin
Cho Chul-Hyun
Heo Jung-Yoon
Kim Ki-Won
Lee Heon-Jeong
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Abstract
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This paper aimed to review currently available cohort studies of subjects with mood disorders such as major depressive disorder (MDD) and bipolar disorder (BD). Using the PubMed and KoreaMed databases, we reviewed eight major cohort studies. Most studies recruited participants with MDD and BD separately, so direct comparison of factors associated with diagnostic changes was difficult. Regular and frequent follow-up evaluations utilizing objective mood ratings and standardized evaluation methods in a naturalistic fashion are necessary to determine detailed clinical courses of mood disorders. Further, biological samples should also be collected to incorporate clinical findings in the development of new diagnostic and therapeutic approaches. An innovative cohort study that can serve as a platform for translational research for treatment and prevention of mood disorders is critical in determining clinical, psychosocial, neurobiological and genetic factors associated with long-term courses and consequences of mood disorders in Korean patients.
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KEYWORD
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Cohort study, Mood disorder, Bipolar disorder, Major depressive disorder, Review
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