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KMID : 1118520170140010044
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Psychiatry Investigation
2017 Volume.14 No. 1 p.44 ~ p.50
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Prevalence of Metabolic Syndrome in Patients with Schizophrenia in Korea: A Multicenter Nationwide Cross-Sectional Study
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Lee Jung-Sun
Kwon Jun-Soo
Kim Dae-Ho
Kim Sung-Wan
Kim Jae-Jin
Kim Jong-Hoon
Nam Hee-Jung
Ryu Seung-Hyong
Park Il-Ho
An Suk-Kyoon
Oh Hong-Seok
Won Seung-Hee
Lee Kang-Uk
Lee Kyu-Young
Lee Seung-Hwan
Lee Yu-Sang
Yi Jung-Seo
Hong Kyung-Sue
Joo Yeon-Ho
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Abstract
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Objective : We designed a nationwide study with limited exclusion criteria to investigate the prevalence of metabolic syndrome (MetS) in Korea and its relationship with antipsychotic medications.
Methods : This multicenter, cross-sectional, and observational study included patients diagnosed with schizophrenia or schizoaffective disorder. Sixteen hospitals enrolled 845 patients aged 18 to 65 years prescribed any antipsychotic medication between August 2011 and August 2013. MetS was diagnosed using the criteria of the modified Adult Treatment Panel III of the National Cholesterol Education Program with the Korean abdominal obesity definition (waist circumference ≥85 cm in women, ≥90 cm in men).
Results : The prevalence of MetS in all patients was 36.5% and was significantly higher in men than women (men, 40.8%; women, 32.2%) and was significantly correlated with age [odds ratio (OR) 1.02] and duration of illness (OR 1.03). The prevalence of MetS across antipsychotic drugs in the major monotherapy group was as follows: 18.8% for quetiapine, 22.0% for aripiprazole, 33.3% for both amisulpride and paliperidone, 34.0% for olanzapine, 35% for risperidone, 39.4% for haloperidol, and 44.7% for clozapine.
Conclusion : The prevalence of MetS is very high in patients with schizophrenia or schizoaffective disorder. Screening and monitoring of MetS is also strongly recommended.
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KEYWORD
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Metabolic syndrome, Antipsychotics, Korean population, Schizophrenia, Schizoaffective disorder
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