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KMID : 1118520180150111094
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Psychiatry Investigation
2018 Volume.15 No. 11 p.1094 ~ p.1097
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BDNF Methylation and Suicidal Ideation in Patients with Acute Coronary Syndrome
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Kang Hee-Ju
Bae Kyung-Yeol
Kim Sung-Wan
Shin Il-Seon
Hong Young-Joon
Ahn Young-Keun
Jeong Myung-Ho
Yoon Jin-Sang
Kim Jae-Min
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Abstract
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Objective: Patients with acute coronary syndrome (ACS) are at an increased risk of suicide. It is well known that epigenetic mechanisms may explain the pathophysiology of suicidal behavior including suicidal ideation (SI), but no study has explored these mechanisms in ACS populations.
Methods: In total, 969 patients were initially recruited within 2 weeks of the acute coronary event and, 711 patients were successfully followed up 1 year after ACS. SI was evaluated using the relevant items on the Montgomery-Asberg Depression Rating Scale and covariates potentially affecting SI were estimated.
Results: Brain-derived neurotrophic factor (BDNF) hypermethylation was associated with SI in both the acute and chronic phases of ACS, although the association was not statistically significant in the acute phase after applying Bonferroni’s correction.
Conclusion: These results suggested that BDNF hypermethylation may have played a role in an epigenetic predisposition for SI in ACS patients, particularly during the chronic phase.
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KEYWORD
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Acute coronary syndrome, Suicidal ideation, Brain-derived neurotrophic factor methylation, Longitudinal study
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