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KMID : 1118520190160070532
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Psychiatry Investigation
2019 Volume.16 No. 7 p.532 ~ p.538
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Normal-But-Low Serum Folate Levels and the Risks for Cognitive Impairment
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Jang Soo-Min
Han Ji-Won
Shin Ji-Yoon
Kim Tae-Hui
Kwak Kyung-Phil
Kim Ka-Young
Kim Bong-Jo
Kim Shin-Gyeom
Kim Jeong-Lan
Kim Tae-Hyun
Moon Seok-Woo
Park Jae-Young
Park Joon-Hyuk
Byun Seon-Jeong
Suh Seung-Wan
Seo Ji-Yeong
So Yoon-Seop
Ryu Seung-Ho
Youn Jong-Chul
Lee Kyoung-Hwan
Lee Dong-Young
Lee Dong-Woo
Lee Seok-Bum
Lee Jung-Jae
Lee Ju-Ri
Jeong Hyeon
Jeong Hyun-Ghang
Jhoo Jin-Hyeong
Han Kyu-Hee
Hong Jong-Woo
Kim Ki-Woong
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Abstract
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Objective: This study aimed to examine the association between normal-but-low folate levels and cognitive function in the elderly population using a prospective cohort study.
Methods: We analyzed 3,910 participants whose serum folate levels were within the normal reference range (1.5-16.9 ng/mL) at baseline evaluation in the population-based prospective cohort study named the “Korean Longitudinal Study on Cognitive Aging and Dementia.” The association between baseline folate quartile categories and baseline cognitive disorders [mild cognitive impairment (MCI) or dementia] was examined using binary logistic regression analysis adjusting for confounding variables. The risks of incident MCI and dementia associated with the decline of serum folate level during a 4-year follow-up period were examined using multinomial logistic regression analysis.
Results: The lowest quartile group of serum folate (≥1.5, ≤5.9 ng/mL) showed a higher risk of cognitive disorders than did the highest quartile group at baseline evaluation (odds ratio 1.314, p=0.012). Over the 4 years of follow-up, the risk of incident dementia was 2.364 times higher among subjects whose serum folate levels declined from the 2nd-4th quartile group to the 1st quartile than among those for whom it did not (p=0.031).
Conclusion: Normal-but-low serum folate levels were associated with the risk of cognitive disorders in the elderly population, and a decline to normal-but-low serum folate levels was associated with incident dementia. Maintaining serum folate concentration above 5.9 ng/mL may be beneficial for cognitive status.
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KEYWORD
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Folate, Elderly, Cognition, Dementia, Cohort studies, Longitudinal studies
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