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KMID : 1118520190160080575
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Psychiatry Investigation
2019 Volume.16 No. 8 p.575 ~ p.580
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Anhedonia and Dysphoria Are Differentially Associated with the Risk of Dementia in the Cognitively Normal Elderly Individuals: A Prospective Cohort Study
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Lee Ju-Ri
Suh Seung-Wan
Han Ji-Won
Byun Seon-Jeong
Kwon Soon-Jai
Lee Kyoung-Hwan
Kwak Kyung-Phil
Kim Bong-Jo
Kim Shin-Gyeom
Kim Jeong-Lan
Kim Tae-Hui
Ryu Seung-Ho
Moon Seok-Woo
Park Joon-Hyuk
Lee Dong-Woo
Youn Jong-Chul
Lee Dong-Young
Lee Seok-Bum
Lee Jung-Jae
Jhoo Jin-Hyeong
Kim Ki-Woong
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Abstract
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Objective: We investigated the impact of depressed mood (dysphoria) and loss of interest or pleasure (anhedonia)on the risk of dementia in cognitively-normal elderly individuals.
Methods: This study included 2,685 cognitively-normal elderly individuals who completed the baseline and 4-year follow-up assessments of the Korean Longitudinal Study on Cognitive Aging and Dementia. We ascertained the presence of dysphoria and anhedonia using the Mini International Neuropsychiatric Inventory. We defined subjective cognitive decline as the presence of subjective cognitive complaints without objective cognitive impairments. We analyzed the association of dysphoria and anhedonia with the risk of cognitive disorders using multinomial logistic regression analysis adjusted for age, sex, education, Cumulative Illness Rating Scale score, Apolipoprotein E genotype, and neuropsychological test performance.
Results: During the 4-year follow-up period, anhedonia was associated with an approximately twofold higher risk of mild cognitive impairment (OR=2.09, 95% CI=1.20?3.64, p=0.008) and fivefold higher risk of dementia (OR=5.07, 95% CI=1.44?17.92, p=0.012) but was not associated with the risk of subjective cognitive decline. In contrast, dysphoria was associated with an approximately twofold higher risk of subjective cognitive decline (OR=2.06, 95% CI=1.33?3.19, p=0.001) and 1.7-fold higher risk of mild cognitive impairment (OR=1.75, 95% CI=1.00?3.05, p=0.048) but was not associated with the risk of dementia.
Conclusion: Anhedonia, but not dysphoria, is a risk factor of dementia in cognitively-normal elderly individuals.
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KEYWORD
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Anhedonia, Dysphoria, Depression, Dementia
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