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KMID : 1118520200170050412
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Psychiatry Investigation
2020 Volume.17 No. 5 p.412 ~ p.416
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Treatment of Children and Adolescents with Epilepsy with Atomoxetine
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Park Kee-Jeong
Ahn Hyun-Ji
Yum Mi-Sun
Ko Tae-Sung
Kim Hyo-Won
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Abstract
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Objective: The objective of this study was to assess the effectiveness and safety of atomoxetine in Korean children and adolescents with epilepsy.
Methods: We retrospectively reviewed the electronic medical records of 105 children and adolescents with epilepsy treated with atomoxetine. Effectiveness was measured with the Clinical Global Impressions-Severity (CGI-S) and/or Clinical Global Impressions-Improvement (CGI-I) scales at baseline, and after 4 and 12 weeks. We defined response to atomoxetine as a CGI-I score less than three at week 12. Safety was evaluated at each visit, based on clinical assessment by a child and adolescent psychiatrist and reports from participants or their caregivers.
Results: In total participants (n=105), 33 (31.4%) showed a response to treatment: a significant decrease in CGI-S scale score was observed over 12 weeks of atomoxetine treatment. The most common adverse event (AE) was decreased appetite (n=16, 15.2%), and life-threatening AEs were not observed. Seizure aggravation due to atomoxetine was observed in 7.6% (n=8) of total participants, and one of them discontinued atomoxetine.
Conclusion: Our results provide preliminary evidence of the effectiveness and safety of atomoxetine in children and adolescents with epilepsy.
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KEYWORD
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Atomoxetine, Effectiveness, Epilepsy, Safety
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