|
KMID : 1118520200170050465
|
|
Psychiatry Investigation
2020 Volume.17 No. 5 p.465 ~ p.474
|
|
|
Shape Deformation in the Brainstem of Medication-Naive Female Patients with Major Depressive Disorder
|
|
Choi Kwan-Woo
Kwon Soon-Wook
Pyun Sung-Bom
Tae Woo-Suk
|
|
|
Abstract
|
|
|
Objective: Although neuroimaging studies have shown volumetric reductions, such as the anterior cingulate, prefrontal cortices, and hippocampus in patients with major depressive disorder (MDD), few studies have investigated the volume of or shape alterations in the subcortical regions and the brainstem. We hypothesized that medication-naive female adult patients with MDD might present with shape and volume alterations in the subcortical regions, including the brainstem, compared to healthy controls (HCs).
Methods: A total of 20 medication-naive female patients with MDD and 21 age-matched female HCs, underwent 3D T1-weighted structural magnetic resonance scanning. We analyzed the volumes of each subcortical region and each brainstem region, including the midbrain, pons, and medulla oblongata. We also performed surface-based vertex analyses on the subcortical areas and brainstem.
Results: Female patients with MDD showed non-significant volumetric differences in the subcortical regions, whole brainstem, and each brainstem region compared to the HCs. However, in the surface-based vertex analyses, significant shape contractions were observed in both cerebellar peduncles located on the lateral wall of the posterior brainstem [threshold-free cluster enhancement, corrected for family-wise error (FWE) at p<0.05] in patients with MDD.
Conclusion: We revealed shape alterations in the posterior brainstem in female patients with MDD.
|
|
|
KEYWORD
|
|
|
Major depressive disorder, Brainstem, Subcortical regions, Magnetic resonance imaging, Female depression
|
|
|
FullTexts / Linksout information
|
|
 
|
|
|
Listed journal information
|
|
  
|
|