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KMID : 1118520200170070702
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Psychiatry Investigation
2020 Volume.17 No. 7 p.702 ~ p.709
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Age-Related Changes in Auditory Nogo-N200 Latency in Medication-Naive Children and Adolescents with Attention-Deficit/Hyperactivity Disorder
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Lee Yeon-Jung
Jeong Mi-Young
Park Seo-Young
Kim Jung-Ho
Kim Ji-Sun
Woo Sung-Il
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Abstract
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Objective: Event-related potential (ERP) changes with brain development in healthy children and adolescents. However, few studies have focused on age-related changes in the N200 and P300 components among individuals with attention-deficit/hyperactivity disorder (ADHD). Therefore, this study aimed to assess age-related differences in the auditory nogo-N200 components in individuals with ADHD.
Methods: We enrolled 46 participants with auditory nogo-N200 and nogo-P300 components. We assessed ADHD symptoms using the Advanced Test of Attention (ATA) and Korean ADHD Rating Scale-IV (K-ARS-IV). Moreover, we assessed emotional and behavioral problems using the Korean Child Behavior Checklist (K-CBCL). Further, we measured auditory ERPs.
Results: There were no differences with respect to sex or ATA, K-ARS-IV, and K-CBCL scores between the groups. With a 1-year increase in age, the nogo-N200 latency at Fz and Cz decreased by 6.08 ms and 4.88 ms, respectively; this result was statistically significant in multivariable linear regression adjusted by sex and dominant hand.
Conclusion: Our findings revealed age-related changes in nogo-N200 latency at the Fz and Cz electrodes in individuals with ADHD. Future studies should perform comparisons with healthy controls to determine whether auditory nogo-N200 can be used to evaluate the developmental level in individuals with ADHD.
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KEYWORD
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Attention-deficit/hyperactivity disorder, Evoked potentials, Electroencephalography, Child, Adolescent
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